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KMID : 0377520030280020121
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Chung-Ang Journal of Medicine
2003 Volume.28 No. 2 p.121 ~ p.126
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The Effect of Fentanyl and Ketorolac in Intravenous Patient-Controlled Analgesia on Postoperative Nausea and Vomiting
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Shin Yeong-Geun
Na Byoung-Su
Park Jung-Won
Woo Young-Cheol
Kim Jin-Yun
Park Sun-Gyoo
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Abstract
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This study was performed to assess the effect of fentanyl and ketorolac in intravenous patient-controlled analgesia (IV-PCA) on postoperative nausea and vomiting. And we also evaluated the antiemetic effect of ondansetron. Ninety three patients who were undergoing elective operation of three departments (gynecology, GY; general surgery, GS; orthopedic surgery, OS) received enflurane anesthesia and IV-PCA. The IV-PCA device was filled with fentanyl 12-15 pg/kg, ketorolac 4-5 mg/kg and normal saline into total dose of 65 ml. After loading 5 ml of the above solution, the IV-PCA was started at a setting of 0.5 ml/h of basal infusion rate and 0.5 ml per demand, with 15 minutes lockout interval. Patients undergoing abdominal surgery were randomly allocated into ondansetron group and non-ondansetron group based on the addition of ondansetron 4 mg into the IV-PCA device. We assessed the incidence of nausea, vomiting by departments and ondansetron usage at operation day (OD), postoperative day 1 (POD1) and 2 (POD2). The incidence of nausea was 34%, 10.3% and 0% at OD in GY, GS and 0s respectively. There was no difference between ondansetron group and non-ondansetron group in the incidence of nausea and vomiting. The patients who received gynecological operation showed higher rate of postoperative nausea and vomiting at OD and PODI. Also, addition of ondansetron into IV-PCA with fentanyl and ketorolac did not reduce the incidence of postoperative nausea and vomiting in abdominal
operation.
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KEYWORD
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Analgesia, Patient-controlled, Fentanyl, Ketorolac, Ondansetron, Vomiting, Nausea, Postoperative
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